It is certainly challenging our ideas of sex and gender when Jesus says in the Gospel of Thomas saying #114 that he will "make Mary male."

But I would note that to become a Christian is to see oneself as a the 'bride of Christ', and so physical males are asked to think of themselves as a female spiritual force.

I take the idea to be that a spiritual adept has to manifest a spiritually bisexed state—a spiritual identity that is the opposite gender to one's biological gender.

I have had Jesus' words in saying #114 in mind in many posts. In my post on Teresa of Avila I noted that she thought Catholic nuns should "be like strong men."

https://medium.com/p/87771e687cbe

Note my new post on Joni Mitchell, the singer-songwriter, who thinks of herself as a Black male. I have noticed women as varied as Princess Diana, Greta Garbo, Emily Dickinson, etc., adopting male guises. Perhaps this is a step in female spiritual development—to be what one is and also what one is not.

I raised GoT saying #114 explicitly in a post on Naomi Wolf having a vision of herself as a boy seeing Jesus.

https://medium.com/belover/naomi-wolfs-jewish-feminist-christianity-49bbf154e0d1

I believe it is defensible to suggest that women, at a high level of spiritual development, can "become male." This is not assigning the male some ultimate spiritual state, but just to say, it is one step along a journey toward the wholeness and totality that is God.