I'm not seeing any rules laid down about genetic proximity in choosing lovers, etc. I've written in some post or other about my reading of 1 Cor 5 being a discussion of Judaizing, as the "father's woman" would be Jews. That divine marriage talk was taken very seriously, I believe.
But of note, Michael Patrick Cover's fascinating paper on Paul's use of the playright Menander. He suggests the "case of incest" concerned a father's concubine.
A son sleeping with a father's concubine was a regular OT situation that pointed, not to incest, but a son using the woman to assert a claim as an heir to the throne. In the Bible, stories about sex are stories about power.